Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue

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Panelists discuss how the assessment and management of immune effector cell–associated neurotoxicity syndrome involves grading symptoms from mild to life-threatening, emphasizing the need for prompt recognition and rapid intervention to prevent progression and minimize long-term neurological damage.

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      Summary for Physicians:

      Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue

      • Dysgeusia (altered taste):
      • Common adverse effect, particularly with chemotherapy and immunotherapy

      • Management:

      • Recommend small, frequent meals with strong flavors (eg, citrus, mint).

      • Suggest using plastic utensils to minimize taste alteration.

      • Encourage good oral hygiene to reduce taste disturbances.
      • Fatigue:
      • Frequently reported, can be persistent and impact quality of life

      • Management:

      • Energy conservation techniques (eg, rest periods, prioritizing tasks)

      • Exercise programs to improve stamina and reduce fatigue

      • Monitor for underlying causes such as anemia or dehydration

      • Address sleep hygiene and manage emotional stress

      Challenges:

      Both symptoms can be challenging to manage long term, requiring personalized strategies and regular assessment.

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