Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue
Panelists discuss how the assessment and management of immune effector cell–associated neurotoxicity syndrome involves grading symptoms from mild to life-threatening, emphasizing the need for prompt recognition and rapid intervention to prevent progression and minimize long-term neurological damage.
EP: 1.ES-SCLC vs LS-SCLC: Critical Differences in Disease Burden and Patient Prognosis
EP: 2.Current Treatment Paradigm: Evolution of First-Line Therapy for ES-SCLC
EP: 3.Addressing Critical Unmet Needs in ES-SCLC Patient Management
EP: 4.Emerging Clinical Trials: Novel Approaches in Second-Line ES-SCLC
EP: 5.Institutional Implementation: Setting Up Tarlatamab Administration
EP: 6.Optimizing Multidisciplinary Coordination for Successful Tarlatamab Implementation
EP: 7.Patient Selection Criteria: Identifying Appropriate Candidates for Tarlatamab
EP: 8.Tarlatamab Administration and Postinfusion Monitoring
EP: 9.Essential Patient and Caregiver Education for Tarlatamab Treatment Success
EP: 10.Neurological Toxicity Recognition: ICANS Assessment and Management
EP: 11.CRS Recognition and Intervention: Timing and Clinical Features
EP: 12.Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue
EP: 13.Differential Toxicity Profile: Tarlatamab vs Traditional Cytotoxic Therapies
EP: 14.Standardized Toxicity Grading: Institutional Protocols for CRS and ICANS
EP: 15.Future Research Priorities: Optimizing Tarlatamab Administration and Toxicity Management
EP: 16.Seamless Transitions: Managing the Inpatient to Outpatient Care Continuum
EP: 17.Complex ES-SCLC Case: Tarlatamab Management Through Toxicity to Clinical Benefit
Summary for Physicians:
Nonimmune Adverse Effects: Managing Dysgeusia and Fatigue
- Dysgeusia (altered taste):
- Common adverse effect, particularly with chemotherapy and immunotherapy
- Management:
- Recommend small, frequent meals with strong flavors (eg, citrus, mint).
- Suggest using plastic utensils to minimize taste alteration.
- Encourage good oral hygiene to reduce taste disturbances.
- Fatigue:
- Frequently reported, can be persistent and impact quality of life
- Management:
- Energy conservation techniques (eg, rest periods, prioritizing tasks)
- Exercise programs to improve stamina and reduce fatigue
- Monitor for underlying causes such as anemia or dehydration
- Address sleep hygiene and manage emotional stress
Challenges:
Both symptoms can be challenging to manage long term, requiring personalized strategies and regular assessment.
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