Reovirus Agent Shows Activity in Phase I Trial
Results from Oncolytics Biotech's phase I trial of Reolysin, its oncolytic reovirus, show stable disease in 7 of 32 patients with advanced or metastatic solid tumors refractory to standard therapy or for which no curative standard therapy exists. Dr. Timothy Yap of The Institute of Cancer Research, Sutton, UK, presented the study at the 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
PRAGUE, Czech RepublicResults from Oncolytics Biotech's phase I trial of Reolysin, its oncolytic reovirus, show stable disease in 7 of 32 patients with advanced or metastatic solid tumors refractory to standard therapy or for which no curative standard therapy exists. Dr. Timothy Yap of The Institute of Cancer Research, Sutton, UK, presented the study at the 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (abstract 348).
Two patients with colorectal cancer had tumor stabilization lasting 3 months and 6 months, along with reductions in CEA of 27% and 60%, respectively, Dr. Yap said. One patient with metastatic prostate cancer had stable disease for 4 months, a 50% decrease in PSA, and extensive necrosis. A patient with metastatic bladder cancer had stable disease for 4 months and a minor response in a metastatic lymph node lesion (reduction from 2.5 to 1.9 cm). Patients with pancreatic cancer, non-small-cell lung cancer, and endometrial cancer also had stable disease lasting 4 to 5 months.
The agent has been well tolerated, Dr. Yap said, and the maximum tolerated dose has not been reached.
Prolaris in Practice: Guiding ADT Benefits, Clinical Application, and Expert Insights From ACRO 2025
April 15th 2025Steven E. Finkelstein, MD, DABR, FACRO discuses how Prolaris distinguishes itself from other genomic biomarker platforms by providing uniquely actionable clinical information that quantifies the absolute benefit of androgen deprivation therapy when added to radiation therapy, offering clinicians a more precise tool for personalizing prostate cancer treatment strategies.
CCR Scores and Beyond: Precision Strategies for Treatment Intensification in Prostate Cancer
April 15th 2025Alvaro Martinez, MD discusses how emerging genomic risk stratification tools such as the clinical cell-cycle risk (CCR) score are transforming personalized prostate cancer treatment by enabling more nuanced assessments of metastasis risk and treatment intensification strategies beyond traditional NCCN risk groupings.
