Roswell Park to Administer "Old" Drug in a New Way

Publication
Article
OncologyONCOLOGY Vol 11 No 4
Volume 11
Issue 4

Roswell Park Cancer Institute is currently recruiting patients for the first phase I study to test a novel method of delivering cisplatin (Platinol) to tumors. The new treatment, called SPI-77, carries cisplatin via a special vehicle called a STEALTH

Roswell Park Cancer Institute is currently recruiting patients for thefirst phase I study to test a novel method of delivering cisplatin (Platinol)to tumors. The new treatment, called SPI-77, carries cisplatin via a specialvehicle called a STEALTH liposome.

"Although other drugs have been placed successfully into liposomesor 'fat envelopes,' it has been very difficult to do the same with cisplatin,"explained Patrick Creaven, md, phd, senior investigator, Department ofSolid Tumor Oncology and Investigational Therapeutics at Roswell Park.

Cisplatin stays in the bloodstream for only a short time, and much ofthe drug is destroyed before it reaches cancer cells. Fat envelopes mayprotect the cisplatin and increase the chance that the drug will reachcancer cells, but ordinary liposomes are rapidly removed from the bloodstream.In contrast, the STEALTH liposome, developed by the Sequus Corporation(Menlo Park, California), stays in the bloodstream for many hours.

"STEALTH liposomes allow us to administer larger, more effectiveamounts of a powerful chemotherapy, with fewer side effects," explainedDr. Creaven.

Enrollment in the Roswell Park study is limited to 30 to 35 patientswith advanced cancer who are not candidates for conventional therapies.The researchers hope to determine optimal drug dosages, evaluate side effects,and identify--and later target--those cancers that respond best to theSPI-77 therapy.

The study, which is already in progress, will continue for approximately6 to 9 months. For general enrollment information on the study, call ElmerBerghom, rn, at 716-845-3114.

Recent Videos
4 experts in this video
4 experts in this video
Ongoing research suggests environmental exposures and the role of microbiomes may influence bladder cancer development and response to treatment.
Providing easier access to ancillary services for patients with PDAC who live farther away from the treatment center may help them complete the treatment regimen.
Future research will aim to assess the efficacy of PIPAC-MMC plus systemic therapy vs systemic therapy alone in patients with peritoneal tumors.
Although small incision surgery may serve as a conduit to deliver PIPAC-MMC, it may confer benefits in the staging and treatment of peritoneal tumors.
Related Content