Significance of GPRC5D as a Target for R/R MM

Opinion
Video

A panel of experts on multiple myeloma discuss the importance of GPRC5D as a target of interest in relapsed/refractory disease and discuss their experiences with talquetamab in clinical practice.

Video content above is prompted by the following:

  • Why is GPRC5D is a target of interest in relapsed/refractory multiple myeloma?
  • Have you had experience using talquetamab in your practice?
Recent Videos
“Every patient [with multiple myeloma] should be offered CAR T before they’re offered a bispecific, with some rare exceptions,” said Barry Paul, MD.
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Elucidating nonresponses to bispecific T-cell engagers may be an important research consideration in the multiple myeloma field.
Fixed treatment durations with bispecific antibodies followed by observation may help in mitigating infection-related AEs, according to Shebli Atrash, MD.
Shebli Atrash, MD, stated that MRD should be considered carefully as an end point, given potential recurrence despite MRD negativity.
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Long-term toxicities like infections and secondary primary malignancies remain a concern when sequencing novel agents for those with multiple myeloma.
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Earlier treatment with daratumumab may be better tolerated for patients with pretreated MRD-negative multiple myeloma.
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