Trends in RCC Incidence
David Aggen, MD, PhD discusses trends in renal cell carcinoma (RCC) incidence.
EP: 1.Trends in RCC Incidence
EP: 2.RCC Histologies
EP: 3.Risk Models and Prognostic Factors
EP: 4.Metastatic RCC: Prognosis and Recent Advances in Care
EP: 5.Biomarker Testing in RCC: Current Approaches
EP: 6.Biomarker Testing: Methodologies, Sample Types, and Emerging Data
EP: 7.Prognostic Value of Biomarkers in RCC
EP: 8.The Role of Genetic Mutations in Prognosis and Decision-Making
EP: 9.Comparison of Older First-Line, Single-Agent Therapies
EP: 10.Newer First-Line Combination Therapy Options
EP: 11.Evolution of Combination Therapy As The Standard of Care
EP: 12.Patients Suitable for First-Line, Single-Agent Therapy and NCCN-Recommended Regimens
EP: 13.Safety and Efficacy Data: The CheckMate 214 Trial
EP: 14.Safety and Efficacy Data: The JAVELIN Renal 101 Trial
EP: 15.Safety and Efficacy Data: The KEYNOTE-426 Trial
EP: 16.Safety and Efficacy Data: The CheckMate 9ER Trial
EP: 17.Safety and Efficacy Data: The CLEAR Trial
EP: 18.Common Adverse Events with Single-Agent or Combination Therapy
EP: 19.Balancing Treatment Efficacy with Toxicity in Metastatic RCC
EP: 20.Strategies for Prevention and Management of Adverse Events
EP: 21.Patient-Specific Factors Impacting Treatment Choices in RCC
EP: 22.Considerations for Patient-Focused, Shared Decision-Making in RCC
EP: 23.Clinical Pearls on Tailoring Dosing Strategies in Metastatic Kidney Cancer
EP: 24.The Importance of Team-Based Management and Patient Communication
EP: 25.OncView™ Podcast: Safety and Efficacy of Available Treatment Options and Considerations for Patient Management in Metastatic RCC
EP: 26.Reflections on Novel Targets and Emerging Regimens for RCC
EP: 27.Clinical Pearls on Recent Advances and the Future of Treatment in RCC
EP: 28.Recap: Safety and Efficacy of Available Treatment Options and Considerations for Management of RCC
Matthew Fowler: Hello, and welcome to this Contemporary CancerNetwork® OncView™ program titled "Metastatic Renal Cell Carcinoma: Safety and Efficacy of Available Treatment Options and Considerations for Patient Management." I'm Matthew Fowler, associate editor with CancerNetwork®. We have with us today Dr David Aggen, medical oncologist at Memorial Sloan Kettering Cancer Center in New York City. Thank you for joining us today, Dr Aggen. Let's get started.
David Aggen, MD, PhD: Thanks for that kind intro, Matt. Happy to speak with you today.
Matthew Fowler: Our first segment focuses on a background of RCC [renal cell carcinoma], so let's set that up. Could you comment on just general RCC incidents; is it increasing, decreasing? Do you have any thoughts on the reasons behind a change that you see?
David Aggen, MD, PhD: Certainly. I think over the past several decades, we've seen a steady increase in the incidents of kidney cancer. In part, that's because our imaging modalities have improved, and as we've started to do CT scans for other reasons, we're incidentally finding small kidney masses. I think that has led to a general trend towards an increase in the number of cases of kidney cancer that we're seeing. We're catching the disease in an earlier state. I also think that there's been an improvement in our diagnostic ability in terms of catching these cancers earlier on and that's sort of led to earlier recognition of this disease entity.
Transcript edited for clarity.
In an OncView™ program, David H. Aggen, MD, PhD, Robert S. Alter, MD, Arnab Basu, MD, MPH, FACP, Mehmet Asim Bilen, MD, and Chung-Han Lee, MD, MPH, offer their expert insights for the treatment of RCC.
