Onvansertib Combo Shows Significant Efficacy in KRAS+ Colorectal Cancer
For patients with KRAS-mutated colorectal cancer, onvansertib plus FOLFIRI/bevacizumab was effective in those who had not received prior bevacizumab.
The Effect of Multidisciplinary Teams for Advancing Research in NETs
Brett L. Ecker, MD, discusses the importance of multidisciplinary collaboration in improving patient outcomes in neuroendocrine tumors.
Capivasertib Combo Significantly Improves rPFS in PTEN-Deficient HSPC
Data show an early trend towards improved overall survival with capivasertib plus abiraterone and androgen deprivation therapy in CAPItello-281.
Bridging Racial and Ethnic Minority Disparities in Pancreatic Cyst Surveillance
A computational linguistics model has mitigated disparities in surveillance of the pancreas that primarily affected racial and ethnic minorities.
SPM AE Incidence After CAR T-Cell Therapy in Lymphoma and Myeloma
Findings from the Phase 3 AURIGA trial support the use of lenalidomide plus daratumumab vs lenalidomide alone as post-transplant maintenance therapy for patients with newly diagnosed multiple myeloma.
Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells
Researchers at SickKids Hospital and McMaster University have developed a novel CAR T-cell therapy targeting ROBO1 for the treatment of recurrent glioblastoma.
Belantamab Mafodotin Combos Accepted for Review by FDA in Multiple Myeloma
A BLA has been accepted by the FDA for 2 belantamab mafodotin combinations that have shown positive results in patients with multiple myeloma.
Advancing Research and Targeting Genomic Alterations in Pancreatic Cancer
Tanios S. Bekaii-Saab, MD, provides an overview of current therapy options and ongoing initiatives involving targetable alterations in those with pancreatic cancer.
Leveraging Community Setting Multidisciplinary Care in Pancreatic Cancer
Genetic consultation and next-generation sequencing can also complement treatment strategies for patients with pancreatic cancer.
Adapting a Computation Linguistics Model to Surveil for Pancreatic Cancer
An advanced computation linguistics model that can detect pancreatic cysts can help patients prevent pancreatic tumors from forming.
Advancing Surgical Techniques in Neuroendocrine Tumors
Brett L. Ecker, MD, focused on the use of de-escalation therapy, which is gaining momentum in neuroendocrine tumors.
Building Upon an “Era of Therapeutic Refinement” in Pancreatic Cancer
Immunotherapy options like CAR T-cell therapy and antigen-presenting cell-directed agents are currently being evaluated in the pancreatic cancer field.
Avoiding CAR T-Cell Collection Problems Following Bridging Therapies
Certain bridging therapies and abundant steroid use may complicate the T-cell collection process during CAR T therapy.
VIOLETTE Trial Shows Precise Planning in Prostate Cancer Microwave Ablation
The VIOLETTE trial, which used OBT-fusion technology for patients with focal ablation of the prostate by microwave needles, released interim results.
FDA Assigns BTD and Receives BLA for RP1 Combo in Advanced Melanoma
Vusolimogene oderparepvec in combination with nivolumab has received breakthrough therapy designation from the FDA in advanced melanoma.
Pancreatic Cancer Incidence Has Risen, Yet Survival Outcomes Have Improved
Pancreatic cancer is projected to become the second-leading cause of cancer-related deaths by 2030 in the United States.
Academic/Community Collaboration May Help Facilitate CAR T Therapy Access
Educating community practices on CAR T referral and sequencing treatment strategies may help increase CAR T utilization.
FDA Updates Fludarabine Phosphate Labeling in Chronic Lymphocytic Leukemia
The updated labeling also includes new information on the recommended dosage of fludarabine phosphate when given with cyclophosphamide and rituximab.
FDA Accepts sNDA for Darolutamide/ADT in Hormone-Sensitive Prostate Cancer
Darolutamide with androgen deprivation therapy has shown promising efficacy and safety results for patients with hormone-sensitive prostate cancer.
Multiple Myeloma Experts Face Off on Sequencing Therapy Options
Experts in multiple myeloma gathered to debate current treatment options in the space during a recent Face Off.
Lung Cancer Home Health Screening Tools May Aid in Triaging LDCT+ Patients
The FirstLook liquid biopsy, when used as an adjunct to low-dose CT, may help to address the unmet need of low lung cancer screening utilization.
FDA OKs Zanidatamab Injection for Metastatic HER2+ Biliary Tract Cancer
Results from the HERIZON-BTC-01 trial led to the approval of zanidatamab for patients with metastatic HER2-positive biliary tract cancer.
Cell-Free DNA Assay Achieves High Negative Predicative Value in Lung Cancer
An 80% sensitivity for lung cancer was observed with the liquid biopsy, with high sensitivity observed for early-stage disease, as well.
EU Approval Recommended for Repotrectinib in ROS1+ NSCLC, NTRK+ Solid Tumors
Results from the TRIDENT-1 and CARE trials, which showcased durable activity and robust responses with repotrectinib, supported the recommendation.
Subcutaneous Pembrolizumab/Chemo Meets Pharmacokinetic Endpoints in NSCLC
For patients with NSCLC, subcutaneous pembrolizumab appeared noninferior vs intravenous pembrolizumab for study end points when combined with chemotherapy.
Optimal Sequencing Between CAR T and Bispecifics in Multiple Myeloma
The use of CAR T-cell therapy and other sequencing options were discussed for patients with multiple myeloma.
Discerning the Best Frontline, Personalized Treatment in Urothelial Carcinoma
“How do we personalize and improve patient selection for frontline treatment now that patients are living, on average, more than 2 years with this aggressive cancer?” said David H. Aggen, MD, PhD
Ensuring Safe Bispecific Antibody Use in Lymphoma at Community Practices
Harmonizing protocols across the health care system may bolster the feasibility of giving bispecifics to those with lymphoma in a community setting.
Addressing Gaps in Education for Non–Clear Cell RCC
A panel discussed on RCC and the differentiation in the identification and treatment of clear and non-clear cell RCC.
FDA Approves FoundationOne Liquid CDx as Diagnostic Tool for NSCLC
FoundationOne Liquid CDx has been approved as a diagnostic tool for tepotinib in patients with non–small cell lung cancer METex14 skipping alterations.
