November 13th 2025
The FDA has approved pertuzumab-dpzb (Poherdy) as a biosimilar to pertuzumab (Perjeta) in breast cancer, based on a review of various attributes, including safety and efficacy data.
November 11th 2025
Data from the ASCENT-07 trial show an early trend toward improved overall survival with sacituzumab govitecan vs chemotherapy.
November 8th 2025
Dato-DXd is being assessed in numerous trials across the breast, lung, and bladder cancer spaces.
November 6th 2025
The safety profile of palazestrant plus ribociclib in a phase 1b trial was comparable to prior reports of each individual agent.
November 5th 2025
Aditya Bardia, MD, highlights the successes and challenges associated with ADC treatments in breast cancer.
IBTR Rates With Margin Widths Not Clinically Meaningful in Breast Cancer
IBTR with the 1 mm and 2 mm cutoff found rates found the margin widths were small and not clinically meaningful.
78 Comparison of Positive Margin Rate of Breast Cancer in Higher BMI Patients
Neoadjuvant Endocrine Therapy Could Sway Breast Cancer Radiation Paradigms
Ninety days of endocrine therapy before surgery could change patient/surgeon preference on concurrent radiation use in those with breast cancer.
79 Case Series of Pathologic Upgrade After Reconstructive Breast Surgery
FDA Approves Multidose Thiotepa Vial for Breast and Ovarian Cancers
The regulatory decision may offer more scheduling flexibility for patients who receive thiotepa for breast or ovarian cancer.
81 Assessing Recurrence Likelihood in Hormone Receptor–Positive/HER2-Negative Breast Cancer Patients Directly From MRI Using Imaging AI
82 Efficacy, Safety, and Biomarker Analysis of ICARUS-BREAST01: A Phase 2 Study of Patritumab Deruxtecan (HER3-DXd) in Patients With HR+/HER2– Advanced Breast Cancer
Same-Day G-CSF After Chemo Appears Safe, Efficacious in Breast Cancer
No grade 3/4 treatment-related adverse effects were observed in patients receiving efbemalenograstim alfa for breast cancer in the Guard-02 trial.
TPS 83 ELAINE 3: Open-Label, Randomized, Multicenter, Phase 3 Study of the Efficacy and Safety of Lasofoxifene Plus Abemaciclib for Treating Locally Advanced or Metastatic, ER+/HER2–, Breast Cancer With an ESR1 Mutation
84 EQUALS: Vaginal/Sexual Health in Patients With Estrogen Receptor–Positive/HER2- Metastatic Breast Cancer
Breast Cancer Disparities May Fuel Guideline-Concordant Care Improvements
Multidisciplinary care can help ensure that treatment planning does not deviate from established guidelines for inflammatory breast cancer management.
86 Elacestrant Combinations in Patients With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer: Update From ELEVATE, a Phase 1b/2, Open-Label, Umbrella Study
87 Elacestrant Plus Abemaciclib Combination in Patients With Estrogen Receptor-positive, HER2-Negative Advanced or Metastatic Breast Cancer
88 Eflapegrastim, a Long-Acting Granulocyte Colony–Stimulating Factor, Administered the Same Day as Chemotherapy in Patients With Early-Stage Breast Cancer: Results From a Multicenter, Open-Label Study
TPS 89 A Randomized Phase 3 Study of First-Line Saruparib (AZD5305) Plus Camizestrant Versus CDK4/6i Plus Physician’s Choice Endocrine Therapy or CDK4/6i Plus Camizestrant in Patients With HR+/HER2– Advanced Breast Cancer With BRCA1/BRCA2/PALB2 Mutations (EvoPAR-B)
Medical Education May Improve Care for Breast Cancer Minority Populations
Photographic and written documentation can help providers recognize inflammatory breast cancer symptoms across diverse populations.
Low Breast Cancer Guideline-Concordant Care Use Indicates Racial Disparities
The use of guideline-concordant care in breast cancer appears to be more common in White populations than Black populations.
90 Contralateral Risk Reduction Mastectomy in Patients With Unilateral Breast Cancer: A Multinational and Multidisciplinary Survey—Physicians’ Perspective
T-DXd With Pertuzumab Improves PFS in HER2+ Metastatic Breast Cancer
Data from the T-DXd monotherapy arm of the phase 3 DESTINY-Breast09 trial will remain blinded until the final PFS analysis.
Sacituzumab Govitecan/Pembrolizumab Yields Significant PFS Improvement in TNBC
Sacituzumab govitecan plus pembrolizumab showed a trend for improved overall survival vs standard of care in patients with untreated PD-L1–positive TNBC.
91 Adverse Effects and Financial Burden of Radiation Therapy in Patients With T3N0M0 Luminal Breast Cancer
92 Near-Infrared Fluorescence Imaging With Indocyanine Green vs Isosulfan Blue for Sentinel Lymph Node Mapping: Comparative Cost Analysis in Early-Stage Breast Cancer
96 Elacestrant Real-World Progression-Free Survival of Adult Patients With ER+/HER2–, Advanced Breast Cancer: A Retrospective Analysis Using Insurance Claims in the United States
97 Treatment Discontinuation Among Patients With Stage IV HER2–Negative Breast Cancer
Bria-IMT Enhances Survival vs Sacituzumab Govitecan in HR+ Breast Cancer
No treatment-related discontinuations have been observed related to Bria-IMT treatment for hormone receptor–positive breast cancer.
Addressing Racial Disparities, Social Barriers to Breast Cancer Care
Strict inclusion criteria may disproportionately exclude racial minority populations from participating in breast cancer trials.
TPS 99 Phase 3, Randomized, Open-Label TroFuse-010 Study of Sacituzumab Tirumotecan Alone and With Pembrolizumab Versus Treatment of Physician’s Choice Chemotherapy in Patients With HR+/HER2– Unresectable Locally Advanced or Metastatic Breast Cancer
100 Non-Pharmacological Interventions for Managing Abemaciclib-Associated Adverse Events in Patients With Early/Advanced HR+/HER2– Breast Cancer: A US-Based Health Care Provider Survey
102 Novel Prognostic and Predictive Locoregional Biosignature for Risk Stratification of Early-Stage Hormone Receptor–Positive Breast Cancer
Miami Breast Cancer Conference Provided Exciting Updates and Engaging Discussions
Neil M. Iyengar, MD, discussed the most prevalent discussions and exciting updates from the 2025 Miami Breast Cancer Conference.