Conclusions from MonumenTAL-1 Study in Multiple Myeloma

EP: 1.How Are Patients with Multiple Myeloma (MM) Diagnosed and Staged?

EP: 2.Overview of Relapsed/Refractory Multiple Myeloma

EP: 3.MonumenTAL-1: Talquetamab in Relapsed/Refractory MM

EP: 4.Talquetamab Safety Profile in Relapsed/Refractory MM

EP: 5.Clinical Strategies for Adverse Event Management in Patients With Multiple Myeloma Receiving Talquetamab

EP: 6.GPRC5D-Related Oral Adverse Events in Multiple Myeloma

EP: 7.MonumenTAL-1: Proactive Management of Oral Toxicities

EP: 8.Multiple Myeloma: Educating Patients on Oral Toxicity Management

EP: 9.Approaches for Managing Dermatologic Adverse Events from Talquetamab in Multiple Myeloma

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EP: 10.Conclusions from MonumenTAL-1 Study in Multiple Myeloma

This is a video synopsis/summary of a Between The Lines series featuring Donna Catamero, ANP-BC, OCN, CCRC; Cesar Rodriguez, MD; and Saad Usmani, MD, MBA, FACP.

In conclusion, talquetamab induces deep, durable responses in heavily pretreated myeloma but has unique, mostly manageable toxicities requiring mitigation to sustain therapy. Up-front patient education on expected adverse effects and self-care, close monitoring and early intervention, and prompt dose modifications when needed facilitate tolerance. Skin changes typically resolve with symptomatic relief from barrier creams. Future studies should examine talquetamab in earlier lines to widen accessibility. As experience accrues, best practices for balancing efficacy and quality of life will evolve through ongoing clinician collaboration.

Video synopsis is AI generated and reviewed by Cancer Network® editorial staff.