MonumenTAL-1: Talquetamab in Relapsed/Refractory MM

EP: 1.How Are Patients with Multiple Myeloma (MM) Diagnosed and Staged?

EP: 2.Overview of Relapsed/Refractory Multiple Myeloma

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EP: 3.MonumenTAL-1: Talquetamab in Relapsed/Refractory MM

EP: 4.Talquetamab Safety Profile in Relapsed/Refractory MM

EP: 5.Clinical Strategies for Adverse Event Management in Patients With Multiple Myeloma Receiving Talquetamab

EP: 6.GPRC5D-Related Oral Adverse Events in Multiple Myeloma

EP: 7.MonumenTAL-1: Proactive Management of Oral Toxicities

EP: 8.Multiple Myeloma: Educating Patients on Oral Toxicity Management

EP: 9.Approaches for Managing Dermatologic Adverse Events from Talquetamab in Multiple Myeloma

EP: 10.Conclusions from MonumenTAL-1 Study in Multiple Myeloma

This is a video synopsis/summary of a Between the Lines series featuring Donna Catamero, ANP-BC, OCN, CCRC; Cesar Rodriguez, MD; and Saad Usmani, MD, MBA, FACP.

Results from the phase 1/2 MonumenTAL-1 trial (NCT03399799) led to FDA approval of talquetamab, a GPRC5D-targeting bispecific antibody, for relapsed/refractory multiple myeloma (MM) after at least 3 prior lines including proteasome inhibitors, immunomodulators, and anti-CD38 antibodies. Patients received step-up dosing of talquetamab 0.4 mg/kg weekly, 0.8 mg/kg every other week, or either schedule after prior T-cell redirection therapy. Overall response rates were 72% to 74% (65% after prior therapy), very good partial response or better rate was 65% (55% after prior therapy), median progression-free survival was 5.1 to 14.2 months, and 12-month duration of response rates for complete response were 79% to 90%. Adverse events included cytokine release syndrome, dysgeusia, dermatologic toxicity, and cytopenias. Infection rates were 59% to 73% (higher after prior therapy).

Rodriguez found talquetamab efficacy and durability comparable to BCMA-directed treatments. Usmani welcomed talquetamab while noting the need for sequencing data between GPRC5D and BCMA targets. Limitations include lack of patients with high-risk disease features to inform effectiveness in these groups.

Video synopsis is AI generated and reviewed by CancerNetwork® editorial staff.