More Notable Trials From SABCS 2008

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Oncology NEWS InternationalOncology NEWS International Vol 18 No 2
Volume 18
Issue 2
Conference|San Antonio Breast Cancer Symposium (SABCS)

Eidtmann H et al: The effect of zoledronic acid on aromatase inhibitor associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36 months follow-up of ZO-FAST (abstract 44).

Eidtmann H et al: The effect of zoledronic acid on aromatase inhibitor associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36 months follow-up of ZO-FAST (abstract 44).

Dowsett M et al: Risk of distant recurrence using Oncotype DX in postmenopausal primary breast cancer patients treated with anastrozole or tamoxifen: A TransATAC study (abstract 53).

Bartlett JMS et al: A prospectively planned pathology study within the TEAM trial confirms that progesterone receptor expression is prognostic but is not predictive for differential response to exemestane versus tamoxifen (abstract 81).

Articles in this issue
Consortium advances multidisciplinary program for colon cancer
Celator joins leukemia society for phase II trial of CPX-351
Genzyme nabs FDA approval for stem cell mobilizing agent
FDA launches pilot safety program for foreign drugs
Radiation oncology society adopts new moniker
Varian places RT units; offers storage system
Improvements in Pap screenings proposed
New outlook for neuroendocrine cancer
Elderly multiple myeloma patients remain responsive to novel therapy teamed with conventional treatment
Mismatched cord blood stem cells meet need for urgent Rx in acute leukemia
Risk of transplantrelated mortality doesn’t increase with cord blood
NSABP B-30: Amenorrhea relates to survival
Easy methods curtail toxins in food linked to cancer in Africa
Growth of Medicare HMOs could impact clinical trials
Trastuzumab in the adjuvant setting: Is concurrent treatment better than sequential?
Recent Videos
Patients with mediastinal lymph node involved-lung cancer may benefit from chemoimmunotherapy in the neoadjuvant setting.
Stressing the importance of prompt AE disclosure before they become severe can ensure that a patient can still undergo resection with curative intent.
Thomas Marron, MD, PhD, presented a session on clinical data that established standards of care for stage II and III lung cancer treatment at CFS 2025.
Sonia Jain, PhD, stated that depatuxizumab mafodotin, ABBV-221, and ABBV-321 were 3 of the most prominent ADCs in EGFR-amplified glioblastoma.
Skin toxicities are common with targeted therapies for GI malignancies but can be remedied by preventative measures and a collaboration with dermatology.
Computational models help researchers anticipate how ADCs may behave in later lines of development, while they are still in the early stages.
ADC payloads with high levels of potency can sometimes lead to higher levels of toxicity, which can eliminate the therapeutic window for patients with cancer.
According to Greg Thurber, PhD, target-mediated uptake is the biggest driver of efficacy for antibody-drug conjugates as a cancer treatment.
Antibody-drug conjugates are effective, but strategies such as better understanding the mechanisms of action may lead to enhanced care for patients with cancer. Antibody-drug conjugates are effective, but strategies such as better understanding the mechanisms of action may lead to enhanced care for patients with cancer.
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