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Evolving Treatment Strategies for Chronic Lymphocytic Leukemia: Insights From Experts Across Mayo Clinic Locations : Episode 2

Navigating 1L Treatment Selection with BTKis in CLL

January 11, 2024
By Sameer A. Parikh, MD
Sikander Ailawadhi, MD
  • Mazie Tsang, MD, MAS, MS
  • Amber Koehler, PA-C, MS

Opinion
Video

Expert faculty discuss consideration factors in guiding frontline treatment selection with BTKis in CLL.

EP: 1.Evolving Front-line Treatment Options for CLL

Now Viewing

EP: 2.Navigating 1L Treatment Selection with BTKis in CLL

EP: 3.Updates on BTKi Monotherapy for CLL in the Frontline Setting

EP: 4.The Role of BTKi + Obinutuzumab for 1L Treatment of CLL

EP: 5.Expert Perspectives on Fixed Duration Therapy with Venetoclax + Obinutuzumab

EP: 6.Updates on Combination Treatment Approaches with BTKi + Venetoclax

EP: 7.Navigating Treatment Selection for CLL in the Relapsed/Refractory Setting

EP: 8.Expert Insights on Extended Follow-Up Data from ALPINE and ELEVATE-RR

EP: 9.Consideration Factors in Treatment Selection for BTKi Therapy in R/R CLL

EP: 10.Key Considerations in Managing Hypertension Risk with BTKis in CLL

EP: 11.Expert Perspectives on Managing Risk of Atrial Fibrillation with BTKis in CLL

EP: 12.Managing Bleeding Risk in Patients with CLL on BTKi Therapy

EP: 13.Utilizing Real-World Data for Informed Decision-Making in CLL

EP: 14.Navigating Treatment Resistance and Sequencing in CLL

EP: 15.Advancements with Novel Treatment Approaches in CLL

EP: 16.Future Perspectives and Unmet Needs in CLL

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More follow-up data will better elucidate the impact of frontline use of hypomethylating agents in patients with myelodysplastic syndromes.
Both clinicians and patients should have as much information as possible to participate in shared decision-making for CLL care, says Jacob D. Soumerai, MD.
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Choosing Between HLA-Mismatched Unrelated and Haploidentical Donors: Donor Age Considerations

Choosing Between HLA-Mismatched Unrelated and Haploidentical Donors: Donor Age Considerations

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July 30th 2025
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Researchers have found that donor age is a key determinant of outcomes in hematopoietic cell transplantation, with younger donors associated with significantly better survival and lower rates of GVHD.

Data from the phase 3 BRUIN CLL-314 trial show a progression-free survival trend favoring pirtobrutinib compared with ibrutinib in patients with CLL/SLL.

Pirtobrutinib Yields Noninferior ORR Vs Ibrutinib in CLL/SLL

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Data from the phase 3 BRUIN CLL-314 trial show a progression-free survival trend favoring pirtobrutinib compared with ibrutinib in patients with CLL/SLL.

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No minimal residual disease-negativity was observed with tuspetinib in patients with AML, including in a patient with more than 7 months of follow-up data.

Tuspetinib Exhibits Enhanced Efficacy in Diverse Newly Diagnosed AML Group

Roman Fabbricatore
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No minimal residual disease-negativity was observed with tuspetinib in patients with AML, including in a patient with more than 7 months of follow-up data.

A panel of clinical pharmacists discussed strategies for mitigating toxicities across different multiple myeloma, lymphoma, and leukemia populations.

Navigating AE Management for Cellular Therapy Across Hematologic Cancers

Tiba Al Sagheer, PharmD, BCOP, BCACP;Rebecca Gonzalez, PharmD, BCOP, FASTCT;Syeda Saba Kareem PharmD, BCOP
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A panel of clinical pharmacists discussed strategies for mitigating toxicities across different multiple myeloma, lymphoma, and leukemia populations.

Leading experts gathered in Orlando, FL, to discuss the current and future state of cellular therapy in oncology at the 2025 ICE-T Symposium.

National ICE-T Conference Aims to Make CAR T Safer and More Available

Tim Cortese
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Leading experts gathered in Orlando, Florida, to discuss the current and future state of cellular therapy in oncology at the 2025 ICE-T Symposium.

An expert panel highlights key presentations in multiple myeloma, lymphoma, and other hematologic malignancies at the 2025 ASCO Annual Meeting.

CAR T and Transplantation Advances Across Hematologic Cancers at ASCO 2025

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Choosing Between HLA-Mismatched Unrelated and Haploidentical Donors: Donor Age Considerations

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Researchers have found that donor age is a key determinant of outcomes in hematopoietic cell transplantation, with younger donors associated with significantly better survival and lower rates of GVHD.

Data from the phase 3 BRUIN CLL-314 trial show a progression-free survival trend favoring pirtobrutinib compared with ibrutinib in patients with CLL/SLL.

Pirtobrutinib Yields Noninferior ORR Vs Ibrutinib in CLL/SLL

Russ Conroy
July 30th 2025
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Data from the phase 3 BRUIN CLL-314 trial show a progression-free survival trend favoring pirtobrutinib compared with ibrutinib in patients with CLL/SLL.

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