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Evolving Treatment Strategies for Chronic Lymphocytic Leukemia: Insights From Experts Across Mayo Clinic Locations : Episode 7

Navigating Treatment Selection for CLL in the Relapsed/Refractory Setting

January 25, 2024
By Sameer A. Parikh, MD
Sikander Ailawadhi, MD
  • Mazie Tsang, MD, MAS, MS
  • Amber Koehler, PA-C, MS

Opinion
Video

A panel of oncology experts share their general approach in navigating treatment selection for patients with R/R CLL, highlighting key factors to consider in making treatment decisions.

EP: 1.Evolving Front-line Treatment Options for CLL

EP: 2.Navigating 1L Treatment Selection with BTKis in CLL

EP: 3.Updates on BTKi Monotherapy for CLL in the Frontline Setting

EP: 4.The Role of BTKi + Obinutuzumab for 1L Treatment of CLL

EP: 5.Expert Perspectives on Fixed Duration Therapy with Venetoclax + Obinutuzumab

EP: 6.Updates on Combination Treatment Approaches with BTKi + Venetoclax

Now Viewing

EP: 7.Navigating Treatment Selection for CLL in the Relapsed/Refractory Setting

EP: 8.Expert Insights on Extended Follow-Up Data from ALPINE and ELEVATE-RR

EP: 9.Consideration Factors in Treatment Selection for BTKi Therapy in R/R CLL

EP: 10.Key Considerations in Managing Hypertension Risk with BTKis in CLL

EP: 11.Expert Perspectives on Managing Risk of Atrial Fibrillation with BTKis in CLL

EP: 12.Managing Bleeding Risk in Patients with CLL on BTKi Therapy

EP: 13.Utilizing Real-World Data for Informed Decision-Making in CLL

EP: 14.Navigating Treatment Resistance and Sequencing in CLL

EP: 15.Advancements with Novel Treatment Approaches in CLL

EP: 16.Future Perspectives and Unmet Needs in CLL

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The medical characteristics of a patient may heavily factor into the selection of tyrosine kinase inhibition for the treatment of chronic myeloid leukemia.
The toxicity profile of interferon and the limited availability of transplantation established a need for TKI development for chronic myeloid leukemia.
We have the current CAR [T-cell therapies], which target CD19; however, we need others.
Current findings from the phase 1/2 CaDAnCe-101 trial show no predictive factors of improved responses with BGB-16673 in patients with CLL or SLL.
More follow-up data will better elucidate the impact of frontline use of hypomethylating agents in patients with myelodysplastic syndromes.
Both clinicians and patients should have as much information as possible to participate in shared decision-making for CLL care, says Jacob D. Soumerai, MD.
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We must work on clinical predictors based on the disease phenotype, we must work on the physician’s attitude, and [we must work to] stimulate the correct and timely usage of ruxolitinib.

Understanding Predictive Markers Drives Ruxolitinib Usage in Myelofibrosis

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According to Francesca Palandri, MD, PhD, ruxolitinib will have a less significant effect in patients with myelofibrosis who have a cytopenic phenotype.


A panel of clinical pharmacists discussed strategies for mitigating toxicities across different multiple myeloma, lymphoma, and leukemia populations.

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Tiba Al Sagheer, PharmD, BCOP, BCACP;Rebecca Gonzalez, PharmD, BCOP, FASTCT;Syeda Saba Kareem PharmD, BCOP
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A panel of clinical pharmacists discussed strategies for mitigating toxicities across different multiple myeloma, lymphoma, and leukemia populations.


The overall safety profile of pirtobrutinib was consistent with previously reported trials across various CLL and SLL settings.

Pirtobrutinib Improves PFS in Treatment-Naïve CLL/SLL Without 17p Deletions

Tim Cortese
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Results from the phase 3 BRUIN CLL-313 trial show that OS trended favorably for pirtobrutinib vs chemoimmunotherapy in this CLL and SLL population.


An expert panel highlights key presentations in multiple myeloma, lymphoma, and other hematologic malignancies at the 2025 ASCO Annual Meeting.

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An expert panel highlights key presentations in multiple myeloma, lymphoma, and other hematologic malignancies at the 2025 ASCO Annual Meeting.


Impact of Posttransplant Cyclophosphamide-Based GVHD Prophylaxis in Patients 70 Years and Older: An Update from BMT CTN 1703

Impact of Posttransplant Cyclophosphamide-Based GVHD Prophylaxis in Patients 70 Years and Older: An Update from BMT CTN 1703

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Researchers from the BMT CTN reported that posttransplant cyclophosphamide-based GVHD prophylaxis significantly improves outcomes for adults aged 70 years and older undergoing allo-HCT.


Reprogramming the Neuroblastoma Tumor Immune Microenvironment to Enhance GPC2 CAR T-cells

Reprogramming the Neuroblastoma Tumor Immune Microenvironment to Enhance GPC2 CAR T-cells

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Researchers at the CHOP have developed a new strategy to improve the effectiveness of GPC2-directed CAR T-cell therapy in neuroblastoma by reprogramming the tumor immune microenvironment.

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