Oncology Peer Review On-The-Go: First-Line Therapeutic Options in Small Cell Lung Cancer

Podcast

In the first episode of a 4-part series, CancerNetwork® spoke with Wade Iams, MD, about the various first-line treat options that are available for patients with small cell lung cancer.

In this special episode of the "Oncology Peer Review On-The-Go" podcast, CancerNetwork® spoke with Wade Iams, MD, a thoracic medical oncologist at the Vanderbilt University Medical Center, about therapeutic advances for small cell lung cancer (SCLC). Iams spotlighted the current first-line therapies that are available for patients with SCLC and the factors considered for treating patients in the first-line setting. He also discussed the phase 3 IMpower133 trial (NCT02763579) evaluating the safety and efficacy of atezolizumab (Tecentriq) in combination with carboplatin and etoposide for patients with extensive stage SCLC and the phase 3 CASPIAN trial (NCT03043872) examining the efficacy and safety of durvalumab (Imfinzi) with or without tremelimumab combined with platinum-based chemotherapy for patients with extensive stage SCLC.

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Recent Videos
Biomarker research is needed to better ascertain patient benefit with tarlatamab among those with relapsed extensive-stage small cell lung cancer.
Less lymphocyte depletion with twice-daily radiotherapy warrants further assessment to optimize the synergistic effect of radiotherapy and immunotherapy.
The recent accelerated approval of tarlatamab marks a significant milestone in treating relapsed extensive-stage small cell lung cancer (ES-SCLC).
Twice-daily thoracic radiotherapy appeared to confer less leukocyte and lymphocyte depletion compared with once-daily radiation in LS-SCLC.
Tarlatamab has demonstrated superiority to lurbinectedin as a treatment for patients with ES-SCLC who have progressed after frontline chemoimmunotherapy.
The clinical adoption of twice-daily accelerated radiotherapy has been limited in North America despite improved outcomes, according to Bin Gui, MD.
Clinical trials in small cell lung cancer appear to be more “pragmatic” with their inclusion criteria than before, according to Anne Chiang, MD, PhD.
CAR T-cell therapies or other agents that impact the immune system in the long term may be important to keep in mind for the management of SCLC.
Employing patient-reported outcomes may help include those with small cell lung cancer in the shared decision-making process.
In the SWOG S2409 PRISM trial, over 800 patients with small cell lung cancer will receive different treatment regimens based on their disease subtype.