Optimal Therapies for Relapsed/Refractory Multiple Myeloma
Nina Shah, MD, details the process to choose optimal therapeutic options for patients with relapsed/refractory multiple myeloma.
EP: 1.Breakthroughs in Therapeutic Options for Relapsed/Refractory Multiple Myeloma
EP: 2.Highlights From the 2021 European Hematology Association Congress on Multiple Myeloma
EP: 3.Upcoming Abstracts on Multiple Myeloma for Presentation at 2021 ASH
EP: 4.Biggest FDA News for Multiple Myeloma in 2021
EP: 5.Treatment Options for Transplant-Eligible Multiple Myeloma
EP: 6.Treatment Options for Transplant-Ineligible Multiple Myeloma
EP: 7.Navigating Individual Treatment for Relapsed/Refractory Multiple Myeloma
EP: 8.Understanding Adverse Events in Multiple Myeloma
EP: 9.BCMA-Directed Agents for Multiple Myeloma
EP: 10.Optimal Therapies for Relapsed/Refractory Multiple Myeloma
EP: 11.Emerging Research and Therapies for Multiple Myeloma
EP: 12.Upcoming Phase 3 Data in Multiple Myeloma
EP: 13.Trials Evaluating Emerging Maintenance Therapy Regimens in Multiple Myeloma
EP: 14.Looking Ahead to the Future of Multiple Myeloma Treatment
EP: 15.Current Leading Therapies for Multiple Myeloma
Nina Shah, MD: For patients with relapsed or refractory myeloma, choosing the most optimal therapy depends on what they had before and what they tolerated. In the earlier lines, the go-to therapy has been a CD38 monoclonal antibody in combination with something. We cannot ignore the very impressive data that has been shown by CD38 monoclonal antibody therapy in combination with carfilzomib [Kyprolis], both from the CANDOR study [NCT03158688] and IKEMA study [NCT03275285]. [We saw] impressive progression-free survival data there. That’s starting to take hold a lot more, especially for patients with aggressive early relapses.
In the later relapses, I’m very impressed with the BCMA [B-cell maturation antigen] CAR T-cell therapy and the BCMA bispecific T-cell engager data. There’s also a potential role for the novel CELMoDs [cereblon E3 ligase modulators] if you incorporate them in combination. Then finally, there are drugs like selinexor [Xpovio] that can be used particularly in combination with other drugs that a patient may have seen long time ago but is ready to be exposed to [again].
Considering NCCN Guidelines to Determine Maintenance Therapy Multiple Myeloma
February 15th 2025During the 66th American Society of Hematology Annual Meeting and Exposition, experts in multiple myeloma gathered to discuss the impact of maintenance therapy and minimal residual disease (MRD) in patients with newly diagnosed transplant-eligible or -ineligible multiple myeloma.
