Voreloxin Gets Orphan Drug Status for Acute Myeloid Leukemia

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OncologyONCOLOGY Vol 23 No 14
Volume 23
Issue 14

Sunesis Pharmaceuticals, Inc, announced that the US Food and Drug Administration has granted voreloxin orphan drug designation for the treatment of acute myeloid leukemia (AML). Sunesis is currently conducting two phase II clinical trials of voreloxin in AML: a single-agent study (REVEAL-1) in newly diagnosed elderly AML patients unlikely to benefit from standard induction chemotherapy and a study evaluating the drug in combination with cytarabine in relapsed/refractory AML.

Sunesis Pharmaceuticals, Inc, announced that the US Food and Drug Administration has granted voreloxin orphan drug designation for the treatment of acute myeloid leukemia (AML). Sunesis is currently conducting two phase II clinical trials of voreloxin in AML: a single-agent study (REVEAL-1) in newly diagnosed elderly AML patients unlikely to benefit from standard induction chemotherapy and a study evaluating the drug in combination with cytarabine in relapsed/refractory AML.

Voreloxin is a first-in-class anticancer quinolone derivative, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arrest, and apoptosis.

Articles in this issue
CYP2D6 Testing in Breast Cancer: Ready for Prime Time?
Tamoxifen, Endoxifen, and CYP2D6: The Rules for Evaluating a Predictive Factor
CYP2D6 Testing for Breast Cancer Patients: Is There More to the Story?
Adult T-cell Leukemia/ Lymphoma: Complexities in Diagnosis and Novel Treatment Strategies
Adjuvant Treatment After Orthotopic Liver Transplantation: Is It Really Necessary?
Recurrent Urothelial Carcinoma With Pulmonary Metastasis
Hepatocellular Carcinoma: The Search for Innovative Adjuvant Therapies
Getting a Handle on Posttransplant Recurrence of HCC
Survivin(g) Adult T-cell Leukemia/Lymphoma
Mediterranean Diet
Mediterranean Diet
Innovative Strategies Improve Outcomes and Reduce Complications Associated With Stem Cell Transplants
Advances in Optimizing Therapy and Quality of Life for People With Hard-to-Treat Blood Cancers
Advances in Genetics and Treatment Protocols Lead to Significant Progress in Leukemia and Myeloproliferative Disorders
Major Cancer Agencies Respond to USPSTF’s New Mammography Guidelines
CMS Releases 2010 Physician Fee Schedule
Recent Videos
Once a patient-specific dose is determined, an all-oral combination of revumenib plus decitabine/cedazuridine and venetoclax may be “very good” in AML.
Daniel Peters, MD, aims to reduce the toxicity associated with AML treatments while also improving therapeutic outcomes.
Patients with AML will experience different toxicities based on the treatment they receive, whether it is intensive chemotherapy or targeted therapy.
A younger patient with AML who is more fit may be eligible for different treatments than an older patient with chronic medical conditions.
Yale’s COPPER Center aims to address disparities and out-of-pocket costs for patients, thereby improving the delivery of complex cancer treatment.
Non-Hodgkin lymphoma and other indolent forms of disease may require sequencing new treatments for years or decades, said Scott Huntington, MD, MPH, MSc.
Fixed-duration therapy may be more suitable for younger patients, while continuous therapy may benefit those who are older with more comorbidities.
Determining the molecular characteristics of one’s disease may influence the therapy employed in the first line as well as subsequent settings.
A 2-way communication between providers and patients may help facilitate dose modifications to help better manage adverse effects.
Treatment with AML depends on a variety of factors, including stage of treatment, transplant eligibility, and mutational status.
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