Lung Cancer

Irinotecan has appeared to have significant activity against previously treated and untreated small-cell lung cancer (SCLC). The major toxicities of irinotecan are neutropenia and diarrhea, although there is interpatient

A number of randomized clinical trials and meta-analyses now support the conclusion that combined modality regimens that include cisplatin (Platinol)-based chemotherapy improve survival in stage III non–small-cell lung

This multicenter study enrolled 73 patients with locally advanced or metastatic non–small-cell lung cancer (NSCLC). The study design was based on the hypothesis that the non-overlapping toxicities of a 3-drug

New cases of lung cancer will be diagnosed in an estimated 164,100 Americans in 2000, and approximately 25% or 41,000 of those cases will be small-cell lung cancer (SCLC). Despite initial sensitivity to chemotherapy, only 10%

Over the last decade, a group of new agents with differing mechanisms of action have shown great promise in early clinical studies in non–small-cell lung cancer (NSCLC). These include the taxanes docetaxel (Taxotere) and

DAVIS, Calif-“Unprecedented” survival times for patients with stage IIIB non–small-cell lung cancer (NSCLC) have resulted from adding taxane sequencing to combined-modality therapy with radiotherapy plus cisplatin (Platinol) and etoposide. These results from the Southwestern Oncology Group (SWOG) 9504 trial were presented at the ASCO meeting by David R. Gandara, MD, of the University of California Cancer Center, Davis.

BOSTON-A regimen of concurrent radiation and weekly administration of paclitaxel (Taxol)/carboplatin (Paraplatin), the most commonly used treatment for nonresectable non–small-cell lung cancer (NSCLC), was evaluated in a national cooperative group trial and shown to be effective.

AMSTERDAM-The use of positron-emission tomography (PET) scans to stage patients with non–small-cell lung cancer (NSCLC) could prevent as many as one in five unnecessary thoracotomies, according to research presented at the ASCO meeting.

KNOXVILLE, Tennessee-An experimental protocol that adds an anti-VEGF agent to carboplatin (Paraplatin)/paclitaxel (Taxol) chemotherapy may improve outcomes more than chemotherapy alone in patients with previously untreated advanced non–small-cell lung cancer (NSCLC).

Smoking-once a socially accepted behavior-is the leading preventable cause of death and disability in the United States. During the first decades of the 20th century, lung cancer was rare; however, as cigarette smoking became increasingly popular,

CHAPEL HILL, NC-In the treatment of non–small-cell lung cancer (NSCLC), combination chemotherapy with paclitaxel (Taxol) and carboplatin (Paraplatin) given before and during radiation therapy may double survival time over that seen with radiation alone.

HELSINKI, Finland-A large phase III international study has shown a survival advantage for neoadjuvant chemotherapy with single-agent docetaxel (Taxotere) in selected patients with stage III non–small-cell lung cancer (NSCLC). The analysis of the study, presented at the ASCO meeting, was, however, met with criticism from investigators outside the study.

Madison, Wis-The largest randomized clinical trial ever conducted in advanced non–small-cell lung cancer (NSCLC) has shown that combination chemotherapy regimens extend survival in advanced disease.

HOUSTON-Improved survival with a very favorable toxicity profile resulted from using weekly single-agent paclitaxel (Taxol) 80 mg/m² in patients with advanced non–small-cell lung cancer (NSCLC) who failed first-line therapy with paclitaxel/carboplatin (Paraplatin).

In October 1999, 40 leading experts from Europe, the United States, and the Far East met in St. Julians, Malta, to discuss recent progress in the management of lung cancer. Emphasis was placed on novel treatment strategies for non–small-cell

Gemcitabine (Gemzar) is a novel deoxycitidine drug that has demonstrated promising single-agent activity in non–small-cell lung cancer and has been proven to be a potent radiosensitizer. Although the exact mechanism of the

Gemcitabine (Gemzar) was originally approved for use in combination with cisplatin (Platinol) for the treatment of advanced non–small-cell lung cancer (NSCLC). Research began to focus on combining gemcitabine with newer

Because the majority of patients with stage IIIA N2 non–small-cell lung cancer (NSCLC) ultimately die of distant metastases, recent efforts to improve their intermediate- and long-term survival have focused on neoadjuvant

The search for new combination chemotherapeutic regimens for the treatment of non–small-cell lung cancer is motivated not only by the desire to increase the objective tumor response and survival rates, but also by the desire

The Hellenic Cooperative Oncology Group conducted a randomized phase III trial to compare paclitaxel (Taxol) 200 mg/m² IV 3-hour infusion on day 1 plus carboplatin (Paraplatin) at an area under the curve (AUC) of 6 (group

In our previous phase I/II studies, both the cisplatin (Platinol), gemcitabine (Gemzar), and vinorelbine (Navelbine) (PGV), and cisplatin, gemcitabine, and paclitaxel (Taxol) (PGT) regimens produced a median survival of

The purpose of this study was to evaluate the combination of gemcitabine (Gemzar), paclitaxel (Taxol), and carboplatin (Paraplatin) in patients with advanced non–small-cell lung cancer (NSCLC). Previously untreated

AstraZeneca has announced the launch of a new website that will help keep researchers and physicians up to date on

Long known to be instrumental in fueling the growth of breast cancer, estrogen may spur the same process in lung cancer, according to the findings of a University of Pittsburgh study presented at the annual meeting of the American Association for

ASCO-Treatment with chemotherapy extends the lives of patients with advanced lung cancer and should become a standard treatment option offered to these patients, according to two papers presented at the 36th Annual Meeting of the American Society of Clinical Oncology (New Orleans).

Researchers at Memorial Sloan Kettering Cancer Center are examining the effectiveness of bringing psychological support into the homes of women with advanced stages of lung cancer through telephone and videophone counseling programs

NEW YORK-Resection with intent to cure was possible for all but one of the lung cancers identified in a German screening program using low-dose spiral CT scans. Of the 13 cancers identified, eight were stage I, Stefan Diederich, MD, a staff radiologist at the University of Münster, said at the Second International Conference on Screening for Lung Cancer. The inoperable lesion was stage IIIB. However, it was resected after preoperative chemotherapy. One lesion was small-cell cancer, six were adenocarcinomas, and six were squamous cell carcinomas.

NEW YORK-As the Early Lung Cancer Action Project (ELCAP) continues to focus on lung cancer screening and diagnosis, a consensus has been reached on a number of points affecting the future of the research and variants of its single-arm design.

NEW YORK-The main challenges in the continuing development of low-dose spiral CT screening for lung cancer are “cost, flow, and efficiency,” Stanley H. Fox, PhD, General Electric Med Systems, Milwaukee, said at the Second International Conference on Screening for Lung Cancer.

NEW YORK-The National Cancer Institute (NCI) is designing a randomized controlled trial of low-dose spiral CT lung cancer screening that would enroll 88,000 Americans.