NCCN Guidelines Recommend Use of FES PET Imaging in ER+ Breast Cancer
18F-Fluorestradiol is currently the only imaging agent approved by the FDA for assessing estrogen receptor–positive lesion status to better guide treatment decision-making.
Breast Cancer Survivors May Benefit From Phone-Based Weight Loss Program
Data from a phase 3 study indicate that weight loss intervention with a telephone-based program appears to be effective across all subgroups of breast cancer survivors.
Frontline Pembrolizumab Combo Improves Survival Vs Placebo in Cervical Cancer
Pembrolizumab plus chemotherapy with or without bevacizumab yields a survival benefit in PD-L1 positive patients with cervical cancer in the phase 3 KEYNOTE-826 trial.
Health Systems May Reduce Leukemia Survival Disparities in Low-Income Populations
Sustained improvements in leukemia outcomes in low- and middle-income countries are feasible with cross border programs, according to an expert from the University of California, San Diego.
Voruciclib/Venetoclax Shows Early Disease Control in Acute Myeloid Leukemia
Voruciclib plus venetoclax appears to yield no dose-limiting toxicities in a small population of patients with acute myeloid leukemia, according to early findings from a phase 1 study.
MRD Tracking May Allow More ‘Individualized’ Management of Multiple Myeloma
C. Ola Landgren, MD, PhD, illustrated how minimal residual disease tracking may allow greater treatment personalization in the future.
Sitravatinib/Nivolumab Fails to Improve Survival Vs Docetaxel in NSCLC
Patients with nonsquamous non–small cell lung cancer experiencing clinical benefit with sitravatinib plus nivolumab in the phase 3 SAPPHIRE trial are eligible to remain on treatment.
Anti-FSP Antibodies May Predict ICI Outcomes in Lung Cancer
Findings from a study suggest that anti-frameshift peptide antibodies may also predict incidence of immune-related adverse effects in patients with lung cancer following immune checkpoint inhibitor therapy.
ATG-022 Receives FDA Orphan Drug Designation for Gastric/Pancreatic Cancers
Claudin 18.2–targeting antibody-drug conjugate ATG-022 is under assessment as part of the phase 1 CLINCH study in patients with advanced or metastatic solid malignancies.
Chinese Regulators Accept sBLA for Toripalimab/Chemo in Advanced TNBC
Supporting data for the supplemental new drug application for toripalimab plus chemotherapy in recurrent metastatic triple-negative breast cancer come from the phase 3 TORCHLIGHT study.
Milademetan Does Not Improve Survival Vs Trabectedin in Liposarcoma
Manufacturers plan to halt further development of milademetan for liposarcoma following the publication of topline results from the phase 3 MANTRA trial.
The Future of Immunotherapy is ‘Bright’ in Multiple Myeloma
C. Ola Landgren, MD, PhD, speaks about transplant eligibility, as well as new therapies and minimal residual disease negativity, in the multiple myeloma space.
FDA Clears IND for AFM13/AB-101 in R/R Classical Hodgkin Lymphoma
Investigators plan to initiate a phase 2 study evaluating AFM13 plus AB-101 in patients with relapsed/refractory classical Hodgkin lymphoma in the first half of 2024.
Roxadustat Demonstrates Noninferiority in Chemotherapy-Induced Anemia
Plans have been made to file a new drug application in China for roxadustat as a treatment for chemotherapy-induced anemia in those with non-myeloid malignancies.
FDA Gives Orphan Drug Designation to Mitazalimab in Pancreatic Cancer
Mitazalimab is currently under investigation in combination with chemotherapy as a treatment for patients with metastatic pancreatic ductal adenocarcinoma in the phase 2 OPTIMIZE-1 trial.
Asciminib May Improve HRQOL Vs Bosutinib in Resistant/Intolerant CML-CP
Asciminib does not appear to interfere with the general life activities of patients with resistant/intolerant chronic phase chronic myeloid leukemia in the phase 3 ASCEMBL trial.
FDA Grants Priority Review to Breast Cancer Imaging Agent
The FDA also accepts a premarket approval application for the Lumicell Direct Visualization System in the breast cancer space.
T-DXd May Maintain HRQOL, Delay Deterioration in HER2+ Metastatic Breast Cancer
Hospitalization rates appear to be comparable between patients receiving trastuzumab deruxtecan and trastuzumab emtansine for HER2-positive breast cancer in the phase 3 DESTINY-Breast03 study.
GEN-001/Avelumab Elicits Positive Responses in Advanced Gastric/GEJ Cancer
Investigators say that they do not have any safety concerns regarding GEN-001 and avelumab in patients with advanced gastric or gastroesophageal junction adenocarcinoma.
FDA Approves Avapritinib in Indolent Systemic Mastocytosis
Adult patients with indolent systemic mastocytosis can now receive avapritinib following the FDA’s approval of the agent.
Trimodality Therapy Yields Similar Outcomes Vs Radical Cystectomy in MIBC
Findings from a retrospective analysis highlight no significant differences in metastasis-free survival in patients with muscle-invasive bladder cancer who received radical cystectomy vs trimodality therapy.
An Examination of Modern Multidisciplinary Practices Vs ‘Old-School’ Cancer Care
C. Ola Landgren, MD, PhD, discusses the benefits obtained when patients have access to a full team of diverse caregivers rather than just a single physician.
Team-Based Approach Improves Integrative Care in Kidney Cancer
Santosh Rao, MD, discusses ongoing and potential future research efforts aiming to maximize the benefits that patients with kidney cancer may derive from integrative oncology treatment techniques.
Treatment Options and Unmet Needs Evaluated in Multiple Myeloma
C. Ola Landgren, MD, PhD, reviewed the plethora of emerging treatment options in multiple myeloma, and how unmet needs in the space can be overcome.
Personalized Therapy Options Are on the Horizon in Multiple Myeloma
Ashley E. Rosko, MD, reviews unmet needs and treatment sequencing for patients with multiple myeloma.
The Complexities and Art of Interpreting Biomarkers and Response to Immune Checkpoint Inhibitors
Ben Kong, PharmD, BCPS, shares a perspective on a study of biomarkers published recently in ONCOLOGY.
Integrative Modalities Are ‘Extremely Safe’ in Kidney Cancer Care
Santosh Rao, MD, discusses guideline recommendations and therapeutic techniques that underscore the current integrative oncology landscape for patients with kidney cancer.
FDA Approves Epcoritamab for Relapsed/Refractory DLBCL and High-Grade B-Cell Lymphoma
Patients with relapsed/refractory diffuse large B-cell lymphoma can now receive epcoritamab following the FDA’s approval of the agent.
Melatonin Therapy May Minimize Long-Term Fatigue in Breast Cancer
Trial findings indicate melatonin may be a potentially effective solution for reducing the incidence and severity of cancer-related fatigue among patients with breast cancer.
ICIs May be a Safe Option in Cancer Regardless of HIV Diagnosis
Patients with human immunodeficiency virus and cancer may derive clinical benefit from immune checkpoint inhibition with no excess toxicity in non–small cell lung cancer and other cancers.