Phase 3 IMagyn050 Study Does Not Meet Primary Endpoint of PFS
July 13th 2020The study showed that the addition of atezolizumab to bevacizumab, paclitaxel, and carboplatin as a front-line treatment in women with newly diagnosed advanced stage ovarian cancer did not meet its primary endpoint of progression-free survival.
Jun J. Mao, MD, MSCE, on Non-Pharmacological Pain Management in Cancer Survivors
July 10th 2020At the 2020 ASCO Virtual Program, Jun J. Mao, MD, MSCE, presented a study designed to evaluate the comparative effectiveness of electro-acupuncture and auricular acupuncture versus usual care in managing pain in cancer survivors.
Allele-Specific DNA Methylation Mapping Reveals Possible Regulatory Sequence Polymorphisms
July 9th 2020Researchers found that dense allele-specific DNA methylation (ASM) mapping in normal samples plus cancer samples reveals possible candidate regulatory sequence polymorphisms (rSNPS) that are difficult to find by other approaches.
FDA Grants Priority Review to Pembrolizumab Monotherapy for Classical Hodgkin Lymphoma
July 9th 2020The FDA accepted and granted priority review to a supplemental biologics license application for pembrolizumab as monotherapy for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma.
FDA Issues Complete Response Letter for Pembrolizumab plus Lenvatinib in Unresectable HCC
July 8th 2020Merck and Eisai announced that the FDA issued a complete response letter to its accelerated approval applications for the combination use of pembrolizumab plus lenvatinib to treat patients with unresectable hepatocellular carcinoma.
Courtney DiNardo, MD, on Study Methods Evaluating a Doublet, Triplet Regimens in AML
July 8th 2020At the 2020 ASCO Virtual Program, Courtney DiNardo, MD, presented on a study of the combination therapy consisting of ivosenidib plus venetoclax with or without azacytidine patients with IDH1-mutated acute myeloid leukemia.
Karen H. Lu, MD, on Genetic Testing From Patients’ Living Rooms
July 6th 2020At the 2020 ASCO Virtual Scientific Program, Karen H. Lu, MD, presented on findings from the MAGENTA trial, designed to test whether pre and/or post-test genetic counseling is needed to optimally deliver online accessible genetic testing.
FDA Lifts Partial Clinical Hold on Pivotal Phase 2 Trial of Camidanlumab Tesirine
July 6th 2020The FDA lifted the partial clinical hold on the on the pivotal phase 2 trial of camidanlumab tesirine (Cami) – designed to evaluate the antibody drug conjugate in patients with relapsed or refractory Hodgkin lymphoma.
Phase 2 MAESTRO Study Fails to Meet Primary Endpoint of PFS in Head and Neck Cancer
July 5th 2020The study of temsirolimus and cetuximab versus temsirolimus alone in patients with recurrent or metastatic cetuximab-resistant head and neck cancer did not meet its primary end point of improved progression-free survival.
Phase 2 CITYSCAPE Trial Shows Promise for Tiragolumab in NSCLC
July 4th 2020Patients with chemotherapy-naïve, locally advanced, or metastatic non-small cell lung cancer who were treated with tiragolumab plus an anti-PD-L1 agent showed better efficacy versus single-agent checkpoint inhibitor therapy alone.