ONI Names Sharon Krumm, PhD, RN, Editor of Oncology Nursing
October 1st 2001MELVILLE, New York-The publishers of ONI are pleased to announce that Sharon K. Krumm, PhD, RN, will serve as Editor of Oncology Nursing. Dr. Krumm earned her bachelor of science in nursing from the University of Missouri School of Nursing, Columbia, and her MS and PhD from the University of Missouri.
Ibandronate vs Pamidronate in the Treatment of Malignant Hypercalcemia
October 1st 2001Data from the first study to compare ibandronate with pamidronate (Aredia) in the treatment of malignant hypercalcemia were presented at the 37th annual meeting of the American Society of Clinical Oncology. The results demonstrated that rates
Many More Patients Will Be Needed for Trials of the Future
October 1st 2001BOSTON-Targeted anticancer drugs such as trastuzumab (Herceptin) targeting HER-2 and imatinib mesylate (Gleevec) targeting Bcr-Abl represent the potential of genome-based medicine, but the future may not be as close as it seems, according to pharmaceutical executives who spoke at the 2001 Drug Discovery Technology Conference.
FDA Approves Zoledronic Acid for the Treatment of Hypercalcemia of Malignancy
October 1st 2001Novartis announced recently that it received marketing approval from the US Food and Drug Administration (FDA) for zoledronic acid (Zometa), a new generation intravenous bisphosphonate for the treatment of hypercalcemia of malignancy.
Battling Fatigue With Exercise Program and Good Nutrition
October 1st 2001NEW YORK-Keeping fit and eating right is no easy task for the millions of Americans who are overweight and out of shape. For cancer patients, it requires specialized know-how as well as determination, according to experts who gave advice during a Cancer Care, Inc. teleconference on ways to battle fatigue.
HAART Improves Survival in Chemotherapy-Treated, HIV-Related NHL
October 1st 2001SAN FRANCISCO-Use of highly active antiretroviral therapy (HAART) significantly increases disease-free survival among patients with HIV-related non-Hodgkin’s lymphoma (NHL), Michele Spina, MD, of Centro di Riferimento Oncologico, Aviano, Italy, said at the 37th Annual Meeting of the American Society of Clinical Oncology (ASCO abstract 1122).
Zometa for Hypercalcemia of Malignancy
October 1st 2001ROCKVILLE, Maryland-Zometa (zoledronic acid for injection) has received marketing approval from the US Food and Drug Administration for the treatment of hypercalcemia of malignancy. Zoledronic acid represents a new generation of intravenous bisphosphonates. It is currently approved for treating hypercalcemia of malignancy in more than 30 countries.
Rituximab Added to Fludarabine in Untreated CLL Patients
October 1st 2001SAN FRANCISCO-Preliminary results from the Cancer and Leukemia Group B (CALGB)-9712 trial indicate that rituximab (Rituxan) given concurrently with fludarabine (Fludara) improves response in previously untreated chronic lymphocytic leukemia (CLL) patients, compared with a sequential approach. The results were presented at the 37th Annual Meeting of the American Society of Clinical Oncology (ASCO abstract 1116).
Large-Core Needle Biopsy Reduces Need for Surgical Biopsies
October 1st 2001SEATTLE-A fully implemented large-core needle biopsy program can dramatically improve the positive predictive value of surgical biopsy of breast lesions, based on the experience of the Brigham and Women’s Hospital, Boston. Jessica Leung, MD, instructor in radiology, Harvard Medical School, presented the study at the 101st Annual Meeting of the American Roentgen Ray Society.
Shorter Follow-up for Aspiration-Negative Breast Masses
October 1st 2001SEATTLE-A 1-year follow-up with mammography appears to be sufficient to detect any false-negative results of ultrasound-guided fine-needle aspiration in patients with nonpalpable breast masses, according to a study from the Montefiore Medical Center, Bronx, NY. Shalom Buchbinder, MD, director of mammography, presented the study at the 101st Annual Meeting of the American Roentgen Ray Society.
Prevalence of Complementary and Alternative Medicine Use in Cancer Patients
October 1st 2001Interest in complementary and alternative medicine (CAM) has grown dramatically over the past several years. Cancer patients are always looking for new hope, and many have turned to nontraditional means. This study was
Patterns of Chemotherapy Administration in Patients With Intermediate-Grade Non-Hodgkin’s Lymphoma
October 1st 2001Records from 653 patients treated between 1991 and 1998 in the Oncology Practice Patterns Study (OPPS) were analyzed to determine contemporary chemotherapy delivery patterns in patients with intermediate-grade non-
Prevalence of Complementary and Alternative Medicine Use in Cancer Patients
October 1st 2001Interest in complementary and alternative medicine (CAM) has grown dramatically over the past several years. Cancer patients are always looking for new hope, and many have turned to nontraditional means. This study was
Prevalence of Complementary and Alternative Medicine Use in Cancer Patients
October 1st 2001Interest in complementary and alternative medicine (CAM) has grown dramatically over the past several years. Cancer patients are always looking for new hope, and many have turned to nontraditional means. This study was
Prevalence of Complementary and Alternative Medicine Use in Cancer Patients
October 1st 2001Interest in complementary and alternative medicine (CAM) has grown dramatically over the past several years. Cancer patients are always looking for new hope, and many have turned to nontraditional means. This study was
Patterns of Chemotherapy Administration in Patients With Intermediate-Grade Non-Hodgkin’s Lymphoma
Records from 653 patients treated between 1991 and 1998 in the Oncology Practice Patterns Study (OPPS) were analyzed to determine contemporary chemotherapy delivery patterns in patients with intermediate-grade non-
Patterns of Chemotherapy Administration in Patients With Intermediate-Grade Non-Hodgkin’s Lymphoma
October 1st 2001Records from 653 patients treated between 1991 and 1998 in the Oncology Practice Patterns Study (OPPS) were analyzed to determine contemporary chemotherapy delivery patterns in patients with intermediate-grade non-
Medicare Plans Coverage for All Treatments of Actinic Keratoses
October 1st 2001WASHINGTON-Medicare will soon institute a policy to cover all its beneficiaries for treatments to remove actinic keratoses, sun-induced precancerous skin lesions confined to the epidermis. The decision establishes the first national coverage policy for the disorder without restrictions based on lesion or patient characteristics.
No Long-Term Advantage for Complete Response to Neoadjuvant Chemo/RT
September 1st 2001WASHINGTON-Stage II and III rectal cancer patients who achieve a complete response (CR) to neoadjuvant chemoradiation do not enjoy any long-term survival advantage over patients who do not, Mark Onaitis, MD, of Duke University Medical Center, said at the 54th Annual Cancer Symposium of the Society of Surgical Oncology.
Anticonvulsants Can Alter Irinotecan Metabolism
September 1st 2001SAN ANTONIO-Enzyme-inducing antiepileptic drugs (EIAEDs) can significantly alter the metabolism of irinotecan (Camptosar) and should be taken into consideration when treating patients for brain tumors, according to John G. Kuhn, PharmD. Dr. Kuhn is professor of Pharmacology and Medicine at the University of Texas Health Sciences Center in San Antonio, Texas. He discussed data on irinotecan pharmacokinetics from an ongoing North American Brain Tumor Consortium (NABTC) phase I study.
New ‘Goals for Pain Relief’ Scale Proves Reliable in Pilot Study
September 1st 2001SAN DIEGO, California-Patients’ differing goals for pain relief may explain some of the variability in pain outcomes. In an attempt to better understand and document these goals, Marie A. Flannery, RN, MS, a nurse practitioner and senior associate at the University of Rochester Cancer Center, developed a 13-item "goals for pain relief" scale.
Epirubicin/Irinotecan in Advanced Cancers
September 1st 2001WASHINGTON, DC-Irinotecan (Camptosar) and epirubicin (Ellence) both have single-agent activity in a number of cancers, and they have different toxicity profiles. John L. Marshall, MD, and colleagues at the Lombardi Cancer Center in Washington, DC, have been working on a phase I trial of epirubicin in combination with irinotecan in patients with various advanced cancers. Dr. Marshall, associate professor and director of Developmental Therapeutics and GI Oncology at the Lombardi Cancer Center reported that doses had to be lowered after the original protocol produced serious myelosuppression in the first four patients treated, but the study has recently reopened.
Irinotecan Added to SU-5416, 5-FU, and Leucovorin in Phase I/II Trial
September 1st 2001NASHVILLE, Tennessee-Irinotecan (Camptosar) has been added to the combination of SU-5416/5-fluorouracil (5-FU)/leucovorin, and is being tested in a phase I/II study in metastatic colorectal cancer. That study is being conducted at Vanderbilt Medical Center in Nashville, Tennessee. Due to dose-limiting toxicity, the schedule and/or dose will be altered to make it more tolerable, according to Jordan D. Berlin, MD, assistant professor of medicine and oncology at Vanderbilt Medical Center.
Irinotecan/Cisplatin Studied as Initial and as Second-Line Treatment in Upper GI Cancers
September 1st 2001HOUSTON-Irinotecan (Camptosar)/cisplatin (Platinol) is being studied as induction therapy for carcinoma of the esophagus and in a separate trial as second-line therapy of advanced gastric carcinoma. Jaffer A. Ajani, MD, professor of medicine at the University of Texas M. D. Anderson Cancer Center in Houston, Texas, presented information on the two trials.