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Systemic Treatment Options for Brain Metastases from Non–Small-Cell Lung CancerIn this review, we discuss recent clinical investigations that highlight the effects of novel compounds targeting EGFR, ALK, and other receptor oncogenes, as well as the promise of immunotherapy in lung cancer CNS disease.
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Uncovering Epigenetic Targets in CancerDr. Stephen Baylin discusses his 2018 AACR meeting presentation on SU2C research into using epigenetic therapy to boost immune checkpoint therapy.
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Systemic Treatment Options for Brain Metastases from Non–Small-Cell Lung CancerIn this review, we discuss recent clinical investigations that highlight the effects of novel compounds targeting EGFR, ALK, and other receptor oncogenes, as well as the promise of immunotherapy in lung cancer CNS disease.
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Non-Clear Cell RCC: Key Learnings and Future Research DirectionsThe panel discusses key learnings from recent studies in non-clear cell RCC subtypes and the need to better understand disease biology to develop optimized, histology-specific therapies rather than extrapolating clear cell treatment approaches.
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OncoMasTR Assay May Help Some Breast Cancer Patients Avoid ChemoIn this video, Dr. Arman Rahman explains how the OncoMasTR protein assay may help women with breast cancer avoid unnecessary chemotherapy.
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Inhibit CXCR4 to Treat CRC and Pancreatic CancerIn this video, Dr. Douglas Fearon outlines ways that inhibiting CXCR4 may provoke an immune response to treat pancreatic and colorectal cancer.
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The 411 on TCGA: Share ‘Omics’ Data for Precision OncologyIn this video, Dr. Jean Zenklusen describes an NCI tool that enables researchers, clinicians, and patients to access an array of cancer-related data.
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Oncology Peer Review On-The-Go: Debra Patt, MD, PhD, MBA, on Telehealth in Cancer CareCancerNetwork® spoke with Debra Patt, MD, PhD, MBA, about the role of telehealth in caring for patients with cancer during the COVID-19 pandemic and beyond.
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Forecasting PARP Inhibitor Resistance in Breast Cancer PatientsIn this video, Dr. Elizabeth Swisher reviews the use of PARP inhibitors in breast cancer, and the importance of understanding how resistance to these agents develops.
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Xenograft Platform Could Lead to Mouse-Based Clinical TrialsIn this video, Dr. Edison Liu describes a novel patient-derived xenograft platform that might enable development of a mouse-based clinical trials program.
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ctDNA Increase May Predict Regorafenib Response in Advanced CRCIn this video, Pashalina Kehagias discusses how an early increase in ctDNA may predict a poor response to regorafenib in advanced CRC.
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Small-Molecule TKIs: Potential Benefit in Multiple MalignanciesIn this video, Dr. Brian Schwartz highlights several small-molecule TKIs in development with the potential to help patients with several malignancies.
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Breast Cancer and African AncestryIn this video, Dr. Melissa Davis explains how African ancestry may play a role in breast cancer, and ways that genetics might be used to help guide treatment.
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POINT: Chemotherapy vs Abiraterone for the Initial Management of Metastatic Prostate CancerChemotherapy is the best option for the initial management of metastatic prostate cancer.
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COUNTERPOINT: Chemotherapy vs Abiraterone for the Initial Management of Metastatic Prostate CancerAbiraterone has become the first-choice treatment for men with metastatic prostate cancer.
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Improving Adherence to Endocrine Therapy in Women With HR-Positive Breast CancerHere, we discuss how to improve adherence to endocrine therapy in women with HR-positive breast cancer, as well as the side effects and the reasons for discontinuation.
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Immunizing Cancer Patients: Which Patients? Which Vaccines? When to Give?This article provides guidance to oncology clinicians on vaccine recommendations and safety of use in their patients.
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Robert Chapkin on Relationships Between the Gut Microbiome, Diet, and Colorectal CancerIn this Q&A, we discuss the research into the relationships between gut microbiota, diet, and colorectal cancer.
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Erdafitinib in the Treatment of Metastatic Urothelial CarcinomaFrancisco Castro-Alonso, MD, and colleagues describe the effects of the use of erdafitinib in a patient with metastatic urothelial bladder cancer.
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Initiation of ADT in a Man With Locally Advanced Prostate Cancer and Multiple Cardiovascular Risk FactorsA 65-year-old man presented with locally advanced, high-risk prostate cancer. His medical history was remarkable for type 2 diabetes mellitus, and he was an active smoker with a 27 pack-year history.
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Initiation of ADT in a Man With Locally Advanced Prostate Cancer and Multiple Cardiovascular Risk FactorsA 65-year-old man presented with locally advanced, high-risk prostate cancer. His medical history was remarkable for type 2 diabetes mellitus, and he was an active smoker with a 27 pack-year history.
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CDK4/6 Inhibitors: Game Changers in the Management of Hormone Receptor–Positive Advanced Breast Cancer?Here, we review the current use of and potential next directions for CDK4/6 inhibitors in the treatment of patients with HR-positive breast cancer.
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CDK4/6 Inhibitors: Game Changers in the Management of Hormone Receptor–Positive Advanced Breast Cancer?Here, we review the current use of and potential next directions for CDK4/6 inhibitors in the treatment of patients with HR-positive breast cancer.
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Treatment Practices in Metastatic MelanomaAllison Betof Warner, MD, PhD, and the Oncology Brothers share clinical insights on treatment decisions for patients with metastatic melanoma.
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Synthetic Lethality of PARP Inhibitors in Prostate CancerIn this podcast, Dr. Emmanuel Antonarakis discusses his novel clinical trial evaluating PARP inhibitors in high-risk and biochemically recurrent prostate cancer.
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The Stand Up 2 Cancer Colorectal Dream TeamDuring AACR 2018, Dr. Diaz discusses the progress of his laboratory’s colorectal cancer research as part of the Stand Up 2 Cancer Colorectal Dream Team.
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ONS Role in New Guideline for irAE ManagementIn this podcast, Kelly Brassil, PhD, RN, discusses irAEs and ONS’s role in developing an ASCO/NCCN guideline for their management.
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Misinformation Rampant Among Cancer PatientsCancer patients get inundated with advice, but how much of it can be trusted? Patient advocate Suzie Siegel weighs in.
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Halt in Production of Codman Pump Leaves QuestionsMSKCC’s Dr. Nancy Kemeny discusses the impact of a company's decision to halt manufacture of a pump used to treat liver mets from colon and rectal cancers.
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TNM Tumor Staging Revisited: A Look at Updated AJCC GuidelinesUpdates to the 8th edition of AJCC's staging manual include incorporation of more nonanatomic features. Oncology Clinical Specialist Chelsea Backler discussed key changes during the 2018 ONS Congress.
